Explainability of random survival forests in predicting conversion risk from mild cognitive impairment to Alzheimer’s disease

Sarica, Alessia; Aracri, Federica; Bianco, Maria Giovanna; Arcuri, Fulvia; Quattrone, Andrea; Quattrone, Aldo

doi:10.1186/s40708-023-00211-w

Brain Informatics

Table 1 Demographic, clinical, cognitive, CSF and imaging data of sMCI and pMCI groups

From: Explainability of random survival forests in predicting conversion risk from mild cognitive impairment to Alzheimer’s disease

	sMCI (216)	pMCI (171)	Missingness (%)	p-value
Demographic:
Age	74.8 ± 7.4	74.7 ± 6.9	0.0	0.65^a
Gender (M/F)	144/72	105/66	0.0	0.28^b
Education level	15.4 ± 3.1	15.8 ± 2.9	0.0	0.26^a
Biomarker:
APOE4 (0/1/2)	120/76/20	56/88/27	0.0	< 0.001^b
Clinical scale:
CDRSB	1.4 ± 0.8	1.85 ± 0.9	0.0	< 0.001^c
FAQ	2.4 ± 3.5	5.5 ± 4.9	0.77	< 0.001^c
Neuropsychological assessment:
ADAS11	10.4 ± 4.3	13.1 ± 4.1	0.0	< 0.001^c
ADAS13	16.7 ± 6.2	21.3 ± 5.4	0.77	< 0.001^c
ADASQ4	5.5 ± 2.2	7.1 ± 1.9	0.0	< 0.001^c
MMSE	27.3 ± 1.8	26.6 ± 1.7	0.0	< 0.001^c
RAVLT_immediate	33.6 ± 9.9	27.3 ± 6.4	0.0	< 0.001^c
RAVLT_learning	3.8 ± 2.5	2.7 ± 2.1	3.36	< 0.001^c
RAVLT_forgetting	4.5 ± 2.4	4.9 ± 2.1	0.26	0.1^c
RAVLT_perc_forgetting	59.3 ± 33.1	78.7 ± 26.9	0.26	< 0.001^c
LDELTOTAL	4.6 ± 2.7	3.0 ± 2.7	0.0	< 0.001^c
DIGITSCOR	38.8 ± 10.8	34.2 ± 10.8	0.26	< 0.001^c
TRABSCOR	118.5 ± 64.8	147.2 ± 79.3	1.0	< 0.001^c
mPACCdigit	-6.3 ± 3.1	-8.76 ± 2.8	0.0	< 0.001^c
mPACCtrailsB	-6.4 ± 3.2	-8.86 ± 3.1	0.0	< 0.001^c
GDTOTAL	1.54 ± 1.37	1.58 ± 1.36	0.0	0.84^c
COPYSCOR	4.68 ± 0.70	4.58 ± 0.69	0.0	0.15^c
BNTTOTAL	25.86 ± 3.81	25.10 ± 4.24	0.52	0.08^c
CSF:
ABETA42	981.67 ± 532.47	696.68 ± 358.49	50.39	< 0.001^c
TAU	293.04 ± 125.75	335.05 ± 113.67	50.39	0.02^c
PTAU	28.82 ± 14.86	33.47 ± 13.12	50.39	0.03^c
Neuroimaging:
Ventricles	42297.1 ± 24293.2	47201.5 ± 23132.8	1.5	0.002^d
Hippocampus	6722.7 ± 1025.4	6014.1 ± 1020.9	19.1	< 0.001^d
WholeBrain	1011262.1 ± 104469.7	980,820.5 ± 113713.5	1.3	0.008^c
Entorhinal	3548.8 ± 731.5	3015.9 ± 713.8	19.1	< 0.001^d
Fusiform	16894.5 ± 2193.8	15733.7 ± 2471.7	19.1	< 0.001^d
MidTemp	19597.4 ± 2678.6	17524.6 ± 2980.4	19.1	< 0.001^d
ICV	1580838.1 ± 164668.7	1571086.5 ± 174884.8	0.0	0.928^c
FDG	1.16 ± 0.15	1.06 ± 0.12	58.91	< 0.001^c
HCI	7.15 ± 3.50	9.67 ± 3.74	48.32	< 0.001^c
Occurrence of event/censorship (sMCI = 0, pMCI = 1) per time point (in months):
m06	20	22
m12	17	47
m18	21	35
m24	31	36
m36	109	27
m48	18	4

In bold significant result at p < 0.05
^aOne-way ANOVA
^bChi-square test
^cANCOVA with age and gender in covariates
^dANCOVA with age, gender and ICV in covariates

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