Table 3 Definitions and classification for proposed new GO classes

GO Biological Process

Oviposition (GO: 0018991)

Change primary term name to synonym ‘egg-laying behavior’ New definition: the muscle system process resulting in the deposition of eggs (either fertilized or not) upon a surface or into a medium, such as water

is a muscle system process (GO: 0003012), part of ‘egg-laying behavior’

GO Biological Process

Behavior (GO: 0007610)

New classification (see right)

is a response to stimulus (GO: 0050896)

GO Biological Process

Egg deposition

The multicellular organismal reproductive process that results in the movement of an egg from within an organism into the external environment

is a reproductive behavior (GO: 00198098); part of oviposition/egg-laying behavior (GO: 0018991)

GO Biological Process

Positive regulation of egg deposition

Any process that positively regulates the rate, frequency or extent of egg deposition

is a nervous system process (GO: 0050877); part of oviposition/egg-laying behavior (GO: 0018991)

GO Biological Process

Negative regulation of egg deposition

Any process that negatively regulates the rate, frequency or extent of egg deposition

is a nervous system process (GO: 0050877); part of oviposition/egg-laying behavior (GO: 0018991)

GO Biological Process

Neuron-to-neuron extra-synaptic peptide signaling

Any process by which a cellular process within one neuron influences a cellular process within another neuron via a secreted gene product, where this secretion occurs independently of synapses

is a neuron-to-neuron chemical signaling process

GO Biological Process

Neuron-to-neuron chemical signaling

Any process by which a cellular process within one neuron influences a cellular process within another neuron via a secreted molecule

is a cell–cell signaling (GO: 0007267) process

GO Biological Process

Behavioral response to carbon dioxide

The behavior of an organism in response to a carbon dioxide stimulus

is a behavior (GO: 007610); is a response to carbon dioxide (GO: 0010037)

GO Biological Process

Carbon dioxide avoidance behavior

The behavioral response to carbon dioxide which results in the directed movement of a motile cell or organism toward a lower carbon dioxide concentration

is a negative chemotaxis (GO: 0050919); is a behavioral response to carbon dioxide

GO Biological Process

Negative regulation of carbon dioxide avoidance behavior

Any process that negatively influences locomotory behavior directed away from a source or gradient of carbon dioxide

is a nervous system process (GO: 0050877); part of behavioral response to carbon dioxide

GO Biological Process

Positive regulation of carbon dioxide avoidance behavior

Any process that positively influences locomotory behavior directed away from a source or gradient of carbon dioxide

is a nervous system process (GO: 0050877); part of behavioral response to carbon dioxide

GO Biological Process

Adaptation of neuron to stimulus

Any process that results in an increased threshold for induction of neural activity due to prior exposure to the same stimulus

is a negative regulation of membrane depolarization (GO1904180)

GO Biological Process

Sensitization of neuronal response to stimulus

Any process that results in a reduced threshold for induction of neural activity due to prior exposure to the same stimulus

is a positive regulation of response to stimulus (GO: 0048584)

GO Biological Process

Sensitization of behavioral response to stimulus

Any process that results in a reduced threshold for induction of behavioral response due to prior exposure to the same stimulus

is a positive regulation of behavior (GO: 0048520)

GO Biological Process

Sensory adaptation in behavioral response to stimulus

Any process that results in an increased threshold for induction of behavioral response due to prior exposure to the same stimulus

is a negative regulation of behavior (GO: 0048521)

GO Biological Process

Behavior co-ordination process

Any neural process that links the execution or cessation of one behavior to the induction or cessation of another behavior

is a regulation of behavior (GO: 0050795)

GO Biological Process

Signal integration process

Any nervous system process by which different types of input to the nervous system contribute in combination to a behavioral or physiological output

is a nervous system process (GO: 0050877)

GO Molecular Function

CO₂ receptor activity

Binding to and responding, e.g., by conformational change, to changes in the cellular level of carbon dioxide (CO2) or its dissociation products in water

is a signaling receptor activity (GO: 0038023)

ECO Evidence Class

Neuron chemical inhibition assay evidence used in manual assertion

A type of experimental phenotypic evidence that is used in a manual assertion, arising from experiments in which the output from a neuron is inhibited by a chemical

is a experimental phenotypic evidence (ECO: 0000059)

ECO Evidence Class

Synaptic transmission inhibition evidence used in manual assertion

A type of experimental phenotypic evidence, that is used in a manual assertion, arising from experiment in which neuron-to-neuron synaptic transmission is manipulated using inhibitors of synaptic transmission, that is used in a manual assertion

is a experimental phenotypic evidence (ECO: 0000059)

ECO Evidence Class

Mechanical perturbation evidence used in manual assertion

A type of experimental phenotypic evidence, that is used in a manual assertion, arising from experiment in which cellular responses are manipulated using mechanical force,, that is used in a manual assertion

is a experimental phenotypic evidence (ECO: 0000059)

ECO Evidence Class

Long-term exposure or conditioning evidence used in manual assertion

A type of experimental phenotypic evidence, that is used in a manual assertion, arising from experimental treatment involving sustained exposure of an organism to one or more environmental conditions

is a experimental phenotypic evidence (ECO: 0000059)

ECTO Class

Exposure to increasing carbon dioxide

An exposure event involving the interaction of an exposure receptor to increasing amount of carbon dioxide

is a exposure to chemical (ECTO: 0000231)

ECTO Class

Exposure to decreasing carbon dioxide

An exposure event involving the interaction of an exposure receptor to increasing amount of carbon dioxide

is a exposure to chemical (ECTO: 0000231)