Table 2 Categories of neurobiological phenomena modelled with GO–CAM

Neuronal basis of behavior

Receptor or G-protein activity regulates behavior or cell activity

Neuron regulates behavior

G protein activity in specific neuron regulates behavior

Cellular process regulates behavior

GPCR regulates G-protein-activity in specific neuron to regulate behavior

Neuronal activity regulates behavior

Neuromodulation of specific neuron by G protein signaling

Neuronal activity dependent secretion from identified neuron regulates behavior

G protein activity regulates gene expression

Neuronal activity dependent neurotransmitter secretion

G protein activity regulates gene expression cell autonomously

Neuron–neuron interaction

G protein activity regulates neurotransmitter biosynthesis

Activity of Neuron A regulates activity of Neuron B

G protein activity regulates phospholipase activation

Activity of Neuron A regulates activity of Neuron B (synapse-dependent)

G protein signaling activity regulates neuronal activity cell autonomously

Mechanical stimulation of Neuron A regulates activity of Neuron B

GPCR regulates ion channel

Negative autoregulation of neuronal activity

Ion channel regulates neuronal activity via GPCR

Neural activity depends on extra-synaptic signaling

G protein activity regulates neurotransmitter biosynthesis cell autonomously

Environmental influence on behavior or cell activity

GPCR regulates G-protein activity

Environmental input regulates behavior

G protein activity regulates neurotransmitter biosynthesis

Environmental input regulates neuronal activity

Neuromodulation of specific neuron by G protein signaling

Environmental condition regulates neuronal activity

Receptor activity regulates neuronal activity cell autonomously

Environmental condition regulates behavior

Cellular process

Mechanical process regulates neural activity

Neurotransmitter biosynthesis

Environmental input regulates behavior via defined neuron

Neurotransmitter signaling pathway affects behavior

Environmental input regulates gene expression

Biochemical process regulates neural activity

Receptor–ligand interaction

Dense core vesicle exocytosis from identified neuron regulates behavior

Receptor–ligand interaction

Gene activity regulates neural activity

Neurotransmitter regulates neuronal activity via ion channel

Gene activity in identified neuron regulates behavior

Neurotransmitter regulates behavior via specific receptor

Dense core vesicle exocytosis regulates behavior

Neurotransmitter regulates behavior via ion channel in identified neuron

Neuropeptide signaling pathway affects behavior

Neurotransmitter regulates behavior via specific receptor in identified neuron

Neuropeptide signaling pathway affects behavior via identified cell

Neurotransmitter affects identified receptor class

Regulation of gene expression in identified neuron

Ion channel activity regulates behavior or cell activity

Neurotransmitter/neuropeptide activity regulates behavior or cell activity

Ion channel regulates neural activity

Neurotransmitter biosynthesis from identified source neuron regulates behavior

Neuromodulation of specific neuron by ion channel activity

Neurotransmitter biosynthesis regulates behavior

Ion channel regulates membrane potential

Neuropeptide from specific neuron regulates behavior

Ion channel activity in defined neuron regulates behavior

Neurotransmitter activity depends on ion channel

Ion channel activity regulates behavior

Neurotransmitter regulates behavior

Nervous system process

Neurotransmitter regulates neuronal activity

Adaptation to chemical stimulus

Regulation of neurotransmitter activity by upstream neuropeptide activity

Co-ordination of locomotion and neural activity to influence behavior

Regulation of secretion by upstream neuropeptide activity