Fig. 6

Modeling signal integration with the part of relation. Bretscher et al. [13] (Table 5A, this manuscript) found that restoring tax-2 expression to BAG neurons rescued CO₂ avoidance on food, but not off food, suggesting that tax-2-dependent avoidance behavior requires food input. This implies an AND-gated interaction to integrate food and CO₂ signals. A One of the relations in GO–CAM, causally upstream of does not capture the necessity of each input, whereas B part of does imply necessity, as required to capture the AND logic involved in sensory integration. C GO–CAM representation of the author statement listed in Table 2A (this manuscript). D This relation may also be useful for modelling co-ordination of behaviors. Kopchock et al. [42] (Table 5B, this manuscript) found that optogenetic activation of the vulval muscles was insufficient to induce an egg-laying event; instead co-ordination of VM activation with a particular phase in the body bend during locomotion was required