Fig. 3

CeN–CAM models of inputs to neurons and behavior. Cell-specific genetic rescue of a behavioral response to pharmacological treatment or environmental stimuli produces models linking genes, GO molecular functions, GO biological processes, and cells in the C. elegans Gross Anatomy ontology. A Carnell et al. [15] (Table 4D, this manuscript) found that VM-specific expression of ser-1 could rescue serotonin-dependent egg-laying behavior, suggesting that ser-1 is required in VM neurons to induce egg-laying in response to serotonin. The G-protein coupled serotonin receptor activity is part of the positive regulation of egg deposition, because the part of relation is transitive (i.e., there is no need for an additional part of relation connecting these nodes). B [16] (Table 4E, this manuscript) found that npr-1 expression in neuronal subsets that include URX is sufficient to rescue the behavioral response to carbon dioxide. The activity of some CO₂ receptor is implied, leading to the addition of a placeholder term without an enabling gene, indicating an important piece of missing information. This activity can be included in the CO₂ sensing circuit by asserting that it is part of the positive regulation of chemotaxis, along with the npr-1-dependent signaling pathway. C AFD neuron responds to CO₂ removal [13] (Table 4F, this manuscript). Currently, there are no terms within appropriate ontologies to describe temporal features of chemical or physical inputs (e.g., ‘decreasing’). The required definitions are suggested in this paper