Fig. 2

CeN–CAM annotations link cells to behaviors. CeN–CAM annotations link cells to behaviors. Cells such as HSN are represented with unique identifiers in the C. elegans Gross Anatomy Ontology. A Cell ablation phenotypes can be modelled using the generic GO cellular process class to reflect the non-molecular nature of the experiment, and causally upstream of or within relations, allowing for the most inclusive description of the relationship between cellular process and nervous system process terms. Example drawn from Waggoner et al. [72] (Table 4A, this manuscript). B CeN–CAM model describing the role of the acetylcholine biosynthetic process in the VC neuron in the regulation of egg-laying [5] (Table 4B, this manuscript). Because the acetylcholine biosynthetic process can proceed independently of electrical activity, it is modeled as causally upstream of, positive effect, acetylcholine secretion, neurotransmission. C Optogenetic activation of uv1 leads to a decrease in egg-laying [4] (Table 4C, this manuscript). This membrane depolarization process is modelled as part of the negative regulation of egg deposition, a nervous system process