Quantifying numerical and spatial reliability of hippocampal and amygdala subdivisions in FreeSurfer

Kahhale, Isabella; Buser, Nicholas J.; Madan, Christopher R.; Hanson, Jamie L.

doi:10.1186/s40708-023-00189-5

Brain Informatics

Table 1 Intraclass correlation coefficients (ICC), Dice coefficients, Bland–Altman bias as a portion of a volume’s structure (bias as POV), and Bland–Altman bias ranges for Hippocampal Subfields for left and right hemisphere regions (e.g., ICC LH = intraclass correlation coefficients for left hemisphere; Dice RH = Dice coefficient for right hemisphere)

From: Quantifying numerical and spatial reliability of hippocampal and amygdala subdivisions in FreeSurfer

Region	ICC LH	ICC RH	Dice LH	Dice RH	Bias as POV LH (%)	Bias Range LH (%)	Bias as POV RH (%)	Bias Range RH (%)
Parasubiculum	0.929	0.946	0.713	0.710	0.356	0.000–45.834	0.410	0.008–32.920
Presubiculum head	0.924	0.936	0.792	0.792	0.212	0.001–29.992	0.078	0.002–23.345
Presubiculum body	0.960	0.963	0.799	0.791	1.057	0.000–41.021	0.626	0.001–33.210
Subiculum head	0.961	0.959	0.775	0.773	0.130	0.001–27.278	0.085	0.002–25.029
Subiculum body	0.961	0.964	0.823	0.826	0.100	0.004–31.485	0.289	0.002–16.760
CA1 head	0.971	0.979	0.818	0.825	0.106	0.000–22.307	0.260	0.000–16.274
CA1 body	0.948	0.970	0.751	0.780	0.127	0.001–50.541	0.465	0.001–29.594
CA3 head	0.952	0.969	0.662	0.675	0.533	0.000–24.448	0.742	0.000–22.072
CA3 body	0.933	0.950	0.597	0.627	0.413	0.000–55.834	0.973	0.001–27.936
CA4 head	0.966	0.966	0.793	0.800	0.551	0.000–20.589	0.494	0.000–21.287
CA4 body	0.931	0.938	0.767	0.780	0.541	0.002–29.764	0.625	0.002–20.289
GC ML DG head	0.965	0.973	0.617	0.625	0.554	0.001–20.329	0.542	0.002–18.378
GC ML DG body	0.940	0.942	0.592	0.650	0.500	0.000–21.930	0.503	0.001–27.053
Molecular layer HP head	0.971	0.976	0.690	0.692	0.206	0.001–18.600	0.240	0.001–14.279
Molecular layer hp body	0.954	0.961	0.631	0.647	0.495	0.001–25.208	0.558	0.000–18.751
Fimbria	0.936	0.942	0.681	0.679	0.639	0.008–78.157	1.198	0.004–57.572
Hippocampal fissure	0.887	0.888	0.497	0.511	0.443	0.001–41.512	0.586	0.000–45.252
Hippocampal tail	0.954	0.968	0.880	0.890	0.315	0.000–50.169	0.393	0.001–18.664
HATA	0.936	0.945	0.760	0.770	1.049	0.000–34.712	0.216	0.007–26.125
Whole hippocampal body	0.959	0.966			0.365	0.000–27.935	0.435	0.004–15.245
Whole hippocampal head	0.975	0.980			0.227	0.001–19.277	0.273	0.002–13.619
Whole hippocampus	0.976	0.983			0.251	0.001–21.668	0.341	0.000–12.473

Color coding is in accordance with excellent [Bold], good [Italic], poor [Underline] scores for ICCs and Dice coefficients (ICC: 0.90–1.00 [excellent], 0.75–0.89 [good], 0.00–0.74 [poor]; Dice coefficients: 0.70–1.00 [excellent], 0.50–.69 [good], 0–0.49 [poor]). We have also highlighted regions with > 1% bias as a portion of a volume’s structure in Italic
Subfield Abbreviations include: Cornu Ammonis CA, Granule Cell and Molecular Layer of Dentate Gyrus GC-ML-DG, Hippocampus-Amygdala-Transition-Area HATA; Hippocampal Parcellation HP

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