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Fig. 6 | Brain Informatics

Fig. 6

From: Quantitative investigation of memory recall performance of a computational microcircuit model of the hippocampus

Fig. 6

Schematic drawing of a ‘model 1’, b ‘model 2’, and c ‘model 3’. In ‘model 1’, a strong excitatory CA3 input increases BSC firing response, which generates on PC dendrite numerous small amplitude IPSPs, thus producing a very strong inhibitory environment which filters out spurious neuronal activities. In ‘model 2’ a strong BSC inhibitory drive to PC dendrite causes postsynaptically fewer, but with larger amplitude IPSPs. In ‘model 3’, a strong excitatory PC feedback signal to BSC increases its firing response, which generates fewer than ‘model 1’ IPSPs on PC dendrite, and hence a less strong inhibitory environment than ‘model 1’

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