Variations in structural MRI quality significantly impact commonly used measures of brain anatomy

Brain Informatics

Table 4 Relations between subcortical volumes and structural MRI quality (as measured by the CAT12 Toolbox)

Area parcel	t_statistics	p_value	p_adjusted
Left-Thalamus-Proper	− 0.10352	0.91765	0.97864
Left-Caudate	0.18568	0.85288	0.97864
Left-Putamen	1.64437	0.10163	0.22358
Left-Pallidum	1.32804	0.18563	0.31415
brain-stem	1.39762	0.16373	0.30017
Left-Hippocampus	0.87275	0.38381	0.55460
Left-Amygdala	3.26946	0.00126	0.01389
Left-Accumbens-area	0.02680	0.97864	0.97864
Left-VentralDC	0.82099	0.41260	0.55460
Right-Thalamus-Proper	− 0.58969	0.55604	0.67961
Right-Caudate	0.07730	0.93846	0.97864
Right-Putamen	1.71325	0.08817	0.21891
Right-Pallidum	1.74292	0.08284	0.21891
Right-Hippocampus	0.79323	0.42856	0.55460
Right-Amygdala	1.89779	0.05912	0.21678
Right-Accumbens-area	1.48388	0.13937	0.27874
Right-VentralDC	1.01197	0.31274	0.49144
cc-posterior	3.33701	0.00100	0.01389
cc-mid-posterior	1.70579	0.08956	0.21891
cc-central	1.96198	0.05111	0.21678
cc-mid-anterior	2.33941	0.02027	0.14866
cc-anterior	1.96509	0.05075	0.21678

Table displays relations between MRI quality (CAT12 score) and subcortical volumes in Freesurfer’s ASEG atlas. Region is in the first column, and t-statistic (of CAT12 and subcortical volume) is in the second column. The third column is the uncorrected p-value, while the fourth column is this test statistic corrected for multiple comparisons (for all 22 subcortical regions of interest). Bold indicates regions that were p < .05 (uncorrected), while italics indicates regions that were p < .05 (FDR corrected)