Fig. 1

The effect of midazolam on visual paired-associate learning. A A schematic of the two parts of the visual paired-associate learning task consisting of (a) an encoding task, and (b) a cued recall task. B The effect of midazolam on encoding and retrieval of new information after drug administration. Individuals with intravenous midazolam showed a marked decrease in encoding and retrieval trials than subjects with saline. The hippocampus and prefrontal cortex were involved in paired-associate learning and midazolam significantly decreased the activation of hippocampus and prefrontal cortex in trials requiring encoding and retrieval of new information