Predicting the course of Alzheimer’s progression

Brain Informatics

Table 1 Summary measures at baseline for raw and imputed data

Diagnosis category	Outcomes	Imputed data			Raw data
Diagnosis category	Outcomes	n	Mean	SE	n	Mean	SE
Dementia	ADAS13	342	29.91	0.43	330	29.87	0.44
	CDRSB	342	4.39	0.09	338	4.41	0.09
	EcogPtTotal	342	1.91	0.02	144	1.90	0.05
	EcogSPTotal	342	2.75	0.03	145	2.74	0.05
	MMSE	342	23.22	0.11	338	23.22	0.11
	MOCA	342	17.52	0.20	142	17.12	0.38
	RAVLT immediate	342	22.81	0.41	335	22.85	0.41
	FAQ	342	13.14	0.38	337	13.18	0.38
	FDG	342	1.07	0.01	242	1.07	0.01
	Hippocampus/ICV(\(\times \, 100\))	342	0.38	0.00	272	0.38	0.00
	Ventricles/ICV	342	0.03	0.00	315	0.03	0.00
	Entorhinal (mm)	342	2829.35	33.72	254	2819.26	42.54
MCI	ADAS13	872	16.53	0.23	862	16.53	0.23
	CDRSB	872	1.52	0.03	866	1.52	0.03
	EcogPtTotal	872	1.84	0.01	468	1.79	0.02
	EcogSPTotal	872	1.84	0.02	465	1.72	0.03
	MMSE	872	27.59	0.06	866	27.59	0.06
	MOCA	872	22.66	0.09	465	23.41	0.15
	RAVLT immediate	872	34.24	0.36	866	34.24	0.36
	FAQ	872	3.18	0.14	862	3.17	0.14
	FDG	872	1.23	0.00	665	1.25	0.01
	Hippocampus/ICV(\(\times \,100\))	872	0.44	0.00	737	0.44	0.00
	Ventricles/ICV	872	0.03	0.00	836	0.03	0.00
	Entorhinal (mm)	872	3497.43	24.18	733	3497.38	27.67
CN	ADAS13	523	9.24	0.19	520	9.24	0.19
	CDRSB	523	0.04	0.01	520	0.04	0.01
	EcogPtTotal	523	1.41	0.01	290	1.41	0.02
	EcogSPTotal	523	1.22	0.01	288	1.21	0.02
	FAQ	523	0.24	0.04	520	0.24	0.04
	MMSE	523	29.06	0.05	520	29.06	0.05
	MOCA	523	25.54	0.09	287	25.76	0.14
	RAVLT immediate	523	44.66	0.43	518	44.67	0.43
	FDG	523	1.31	0.00	391	1.31	0.01
	Hippocampus/ICV(\(\times \,100\))	523	0.49	0.00	471	0.49	0.00
	Ventricles/ICV	523	0.02	0.00	494	0.02	0.00
	Entorhinal (mm)	523	3828.36	26.57	468	3840.29	29.09

ADAS13 Alzheimer’s Disease Assessment Scale, CDRSB Clinical Dementia Rating—Sum of Boxes, EcogPtTotal everyday cognition participant, EcogSPTotal everyday cognition study partner, FAQ Functional Assessment Questionnaire, FDG FluoroDeoxyGlucose, MMSE Mini-Mental State Examination, MOCA Montreal Cognitive Assessment, RAVLT Rey Auditory Verbal Learning Test, ICV intracranial volume, CN control, MCI mild cognitive impairment, n number of observations, SE standard error