Fig. 4

Association between SNPs and latent variable scores, as found by the robust maximum likelihood fit of the SEM. All nominally significant associations (\(p<0.05\)) are coloured by their robust z-statistic values [23]. The linked genes [25] are shown in brackets. a The results for the training set. After Bonferroni correction for the 315 tests, only the effect of rs429358 (APOE) on the hippocampus region group remains significant. b The validation results confirm the significant effect of rs429358 (APOE) on the hippocampus region group