Two-dimensional enrichment analysis for mining high-level imaging genetic associations

Brain Informatics

Table 3 Top enriched GO terms of GSs from identified GS–BC modules

Group	GS ID	# of genes	GO Category	Corrected p value
Behavior	GS03	55	Behavior	2.2E\(-\)2
			Learning or memory	4.4E\(-\)2
Cell communication	GS01	81	Regulation of synaptic transmission	2.7E\(-\)6
			Neuron-neuron Synaptic transmission	2.9E\(-\)3
	GS03	55	Synaptic transmission	1.7E\(-\)4
Metabolic process	GS05	19	Fat-soluble vitamin metabolic process	4.3E\(-\)2
			Organic hydroxy compound biosynthetic process	4.8E\(-\)2
	GS06	28	Regulation of translational termination	2.8E\(-\)2
Mitochondrion	GS02	168	Mitochondrial membrane part	2.5E\(-\)3
			Mitochondrial respiratory chain complex I	4.9E\(-\)3
Neurological system process	GS03	55	Associative learning	1.1E\(-\)2
			Learning	4.5E\(-\)6
	GS09	111	Detection of chemical stimulus involved in sensory perception	1.1E\(-\)4
			Olfactory receptor activity	1.9E\(-\)5
Response to stimulus	GS03	55	Response to amphetamine	2.0E\(-\)3
			Visual behavior	4.5E\(-\)3
	GS05	19	Response to cholesterol	3.6E\(-\)2
			Response to sterol	3.7E\(-\)2
	GS09	111	Detection of chemical stimulus	1.6E\(-\)4
Signal transduction	GS01	81	Glutamate receptor signaling pathway	7.3E\(-\)4
	GS03	55	Adenylate cyclase-activating dopamine receptor signaling pathway	3.1E\(-\)3
			Dopamine receptor signaling pathway	1.4E\(-\)2
	GS05	19	Transmembrane receptor protein kinase activity	4.4E\(-\)2
	GS09	111	Olfactory receptor activity	1.9E\(-\)5