Fig. 1

Overview of the proposed Imaging Genetic Enrichment Analysis (IGEA) framework. A Perform SNP-level GWAS of brain wide imaging measures. B Map SNP-level GWAS findings to gene-based. C Construct gene-ROI expression matrix from AHBA data. D Construct GS–BC modules by performing 2D hierarchical clustering, and then filter out 2D clusters with an average correlation below a user-given threshold. E Perform IGEA by mapping gene-based GWAS findings to the identified GS–BC modules. F For each enriched GS–BC module, examine the GS using GO terms, KEGG pathways, and OMIM disease databases, and map the BC to the brain